Symbol
Name
ID

Gli2
GLI-Kruppel family member GLI2
MGI:95728

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Microcephaly

Decreased response to growth hormone stimulation test

Ectopic posterior pituitary

Anterior pituitary agenesis

Anterior pituitary hypoplasia

Hypopituitarism

Panhypopituitarism

Optic nerve hypoplasia

Hydrocephalus

Lateral ventricular asymmetry

Abnormal cortical gyration

Thin corpus callosum

Partial agenesis of the corpus callosum

Holoprosencephaly

Alobar holoprosencephaly

Occipital meningocele

Intellectual disability, severe

Global developmental delay

Seizure

Disease(s) Associated with GLI2

Culler-Jones syndrome

holoprosencephaly 9

Mouse Phenotypes

nervous system phenotype

abnormal neuron differentiation

abnormal neural tube morphology

abnormal floor plate morphology

absent floor plate

abnormal cerebellar foliation

abnormal cerebellar lobule formation

reduced cerebellar foliation

abnormal cerebellum external granule cell layer morphology

thin external granule cell layer

hydrocephaly

abnormal cerebellar Purkinje cell layer

abnormal cerebellar granule layer morphology

abnormal cerebellar molecular layer

abnormal cerebellum anterior vermis morphology

abnormal cerebellum vermis morphology

small cerebellum

abnormal motor neuron morphology

abnormal ventral interneuron 3 morphology

abnormal spinal cord morphology

Availability

Mouse Genotype

Gli2^tm1Alj/Gli2^tm1Alj

Gli2^tm2.1Alj/Gli2^tm2.1Alj

Gli2^tm6.1Alj/Gli2^tm6.1Alj

Gli2^tm1Alj/Gli2⁺

Gli2^tm1Alj/Gli2^tm2.1Alj

Gli2^tm1Alj/Gli2^tm6.1Alj

En1^tm2(cre)Gld/En1⁺
Gli2^tm1Alj/Gli2^tm6Alj (conditional)

Gli2^tm1Alj/Gli2^tm6Alj
Tg(Nes-cre)1Kln/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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